Asciminib sara stedy stand aid is a novel tyrosine kinase inhibitor (TKI) that specifically targets the myristoyl pocket.It has increased selectivity and potent activity against BCR-ABL1 and the mutants that most frequently prevent the activity of the ATPbinding competitive inhibitors.Results for clinical trials in patients with chronic myeloid leu
Abstract Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN).The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood.Platelet mitochondria play a role in platelet activation, but their number and function have not been extensively explored in MPN to date.We observed an incre
korpskaft A study was conducted to evaluate morphological characters that were able to be used as indicators of water-deficit tolerance in rice at the germination phase in the Laboratory of Conservation Biology and Biodiversity, Department of Biology, FMIPA, Sam Ratulangi University.The method that was used in this study was germination in the osmo
Low-alloyed TRIP steels are well known since the beginning of the 21st century and used for automotive applications to ensure the passive viqua-f4 safety.However, although their behaviour is fully investigated at a monotonous behaviour, the case of cyclic loading is not well studied.The present work describes in detail the heterogeneous-microstruct